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Women, especially women of color (WOC), STEM faculty are underrepresented in full professor and leadership positions and overrepresented in non-tenure track positions. It is essential to develop organizational-level approaches which foster equitable and sustainable practices that lead to the success of women STEM faculty at Historically Black Colleges and Universities (HBCUs). The purpose of this paper is to share a model for institutional transformation focusing on recruitment, retention, and advancement of women STEM faculty. We describe our approaches, outcomes, challenges, successes, and lessons learned to serve as a model for other institutions. In order to transform our institution, we focused on changes in policy, practice, and programming. Several approaches were implemented to increase the number of women STEM faculty and position them for leadership opportunities. Our outcomes demonstrate that by implementing multi-faceted strategies we have successfully moved the needle for institutional transformation.