Date of Award

2011

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

First Advisor

Waterman, Jenora T.

Abstract

This study investigated markers of oxidative stress and inflammation through proteomic, genomic, and cytokine profile analyses following anthropogenic and biogenic nanoparticle exposure in vitro and the level of cellular response from antioxidant treatments. The overall goal of this study was to perform a comprehensive analysis of the molecular alterations mediated by nanoparticles on the human airway epithelium and substantiate a novel therapeutic antioxidant treatment. Results revealed that swine confinement facility dust upregulated expression of proinflammatory mediator genes in NHBE cells such as prostaglandin endoperoxide synthase 2 or COX-2 after 4hrs of exposure.

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