Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)

First Advisor

Sang, Shengmin


The objective of this study was to investigate the preventive effects of rosemary leaf extract (RE) and its active components on prevention of weight gain and associated metabolic disorders in high-fat-fed mice; determine the effective doses of the chief compound in RE to reduce weight gain and hyperglycemia; and try to understand the underlying anti-obesity mechanism. For this purpose, commercial RE with 45% carnosic acid (CA) was enriched with CA to 80%. Animals were given low-fat diet (LFD), high-fat diet (HFD), high fat with 0.50% RE (enriched with 45% CA, RE#1), high fat with 0.28% w/w RE (enriched with 80% CA, RE#2H), and high fat with 0.14% w/w RE (enriched with 80% CA, RE#2L) for 16-week periods. Physiological and biochemical parameters were monitored.