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Description

Additive Manufacturing (also known as 3D printing) is a versatile technology that can aid in developing personalized medicine while maintaining cost and time efficiency. Currently, fused deposition modeling (FDM) is one of the most common 3D printing techniques used in the production of pharmaceutical drugs. However, FDM faces a few limitations, such as a two-step printing process and exposing material to multiple thermal processing steps, making it disadvantageous for clinical applications. Direct Powder Extrusion (DPE) is a recently developed 3D printing technology that is gaining popularity in the pharmaceutical research industry for its single-step printing process, making it ideal for clinical applications. The present study aims to investigate melt rheology of formulations prepared for Direct Powder Extrusion to develop a pH-dependent drug matrix using Eudragit L100-55 as the base polymer. However, processing Eudragit L100-55 for extrusion application is proving to be a challenge. Thus, by assessing the melt rheology of Eudragit L100-55 based formulations, the printability of the formulation can be evaluated in advance. The Anton Paar MCR 302 Rheometer was used for the rheological investigation. The amplitude sweep test, frequency sweep test, and temperature oscillation ramp test were conducted to investigate formulation rheology at a temperature range of 120-160°C. The findings conclude that investigation of melt rheology is crucial to evaluate formulation printability.

Publication Date

4-1-2025

Keywords

Additive Manufacturing, Rheology, Targeted Drug Delivery

Investigation of Melt Rheology for Direct Powder Extrusion (DPE) 3D Printing

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