Association of Per-and Polyfluoroalkyl Substances with Pan-Cancers associated with Sex Hormones

Elizabeth Olarewaju, Technology Management, Science and Technology, North Carolina Agricultural and Technical State University

Description

Per and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants with potential endocrine-disrupting properties. This study explores the relationship between exposure to multiple PFAS and pan-cancers associated with sex hormones (PCSH), accounting for non-linear interactions. Data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, including 14,373 participants, were analyzed for serum concentrations of six PFAS (PFOA, PFOS, PFHxS, PFDE, PFNA, PFUA) and their association with PCSH. Statistical methods included t-tests, chi-square tests, regression analyses, and Bayesian Kernel Machine Regression (BKMR) to assess complex interactions. PFOS levels were significantly higher in individuals with PCSH (p=0.0022), and ethnicity showed a significant association with PCSH (p