Optimizing Focused Ultrasound-Based Deep Penetrating Acoustic Volumetric Printing for Minimally Invasive Bone Reconstruction

Authors

Iylan Howson, Chemical, Biological, and Bioengineering Department, College of Engineering, North Carolina Agricultural and Technical State University
Muna Aryal Ph.D., Chemical, Biological, and Bioengineering Department, College of Engineering, North Carolina Agricultural and Technical State University

Files

Description

Deep Penetrating Acoustic Volumetric Printing (DAVP) is a groundbreaking technology that addresses the limitations of material choices, build sizes, and penetration depths found in light-based volumetric printing. By integrating focused ultrasound (FUS) with a viscoelastic sono-ink, DAVP allows for noninvasive, precise control of material solidification through localized heating and polymerization. Our project seeks to optimize a multicomponent sono-ink formula for minimally invasive bone reconstruction, ensuring safety and functionality within FDA MI and TI index levels of 2 and 6, respectively. We will evaluate the use of a 1.5 MHz FUS for in-vitro bone defect treatment, utilizing a sono-ink composed of poly(ethylene glycol) diacrylate, agar microparticles, poly(N-isopropylmethacrylamide), APS, and hydroxyapatite nanocomposites. This formulation mimics the physical properties of natural cartilage and will be tested for its mechanical and thermal effects to ensure safe acoustic absorption and solidification. The goal is to demonstrate that the sono-ink can seamlessly bond with native tissue, establishing DAVP's potential for tissue reconstruction and regeneration. Our results will provide the foundation for FDA-approved, minimally invasive DAVP treatments for bone reconstruction, with broader applications in chemotherapy drug delivery and Left Atrial Appendage(LAA) closure, benefiting populations such as children, the elderly, soldiers, and astronauts.

Publication Date

4-1-2025

Keywords

Deep Penetrating Acoustic Volumetric Printing, DAVP, focused ultrasound, sono-ink, sonothermal polymerization, poly(ethylene glycol) diacrylate, PEGDA, agar microparticles, poly(N-isopropylmethacrylamide), PNIPAm, hydroxyapatite nanocomposites, bone reconstruction, tissue engineering, minimally invasive printing, 3D bioprinting, acoustic printing, FDA MI index, FDA TI index, in-situ polymerization, biomedical applications, regenerative medicine

Recommended Citation

Howson, Iylan and Aryal, Muna Ph.D., "Optimizing Focused Ultrasound-Based Deep Penetrating Acoustic Volumetric Printing for Minimally Invasive Bone Reconstruction" (2025). 2025 Honors College Research Symposium. 15.
https://digital.library.ncat.edu/honorscollegesymposium25/15