Date of Award

2012

Document Type

Thesis

First Advisor

Worku, Mulumebet

Abstract

Concerns for animal welfare, food safety, and security fuel interest in understanding modulators of innate immunity. The accumulation of neutrophils and activation of toll-like receptors (TLRs) at infection sites are critical events of innate host defense. The objectives of this study were to evaluate the effects of Lipopolysaccaride (LPS), Peptidoglycan (PGN), Nystatin (NYS), and Quebracho (Q) extract on bovine neutrophils activation in relation to expression of genes encoding TLR2, TLR4, natural resistance-associated macrophage protein 1 (Nramp1), and the cytokines TNF-α and IL-10.

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