Date of Award

2012

Document Type

Thesis

First Advisor

Martin, Patrick

Abstract

Glioblastoma multiforme (GBM) is the most common form of primary brain tumors. It is a highly aggressive tumor, characterized by an increased proliferation rate and a high capacity to invade surrounding tissues. Currently, GBM treatment includes surgical resection followed by chemotherapy and radiation treatment. However, these therapeutic options often do not alter the infiltrative and migratory capacity of GBMs. The invasive migration of glioblastoma multiforme has been associated with CD44, a cell surface glycoprotein and the principle receptor for hyaluronic acid (HA).

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