Date of Award
Glioblastoma multiforme (GBM) is the most common form of primary brain tumors. It is a highly aggressive tumor, characterized by an increased proliferation rate and a high capacity to invade surrounding tissues. Currently, GBM treatment includes surgical resection followed by chemotherapy and radiation treatment. However, these therapeutic options often do not alter the infiltrative and migratory capacity of GBMs. The invasive migration of glioblastoma multiforme has been associated with CD44, a cell surface glycoprotein and the principle receptor for hyaluronic acid (HA).
Edmondson, Rasheena DeCarroll, "The Role Of Fra-1 And Cd44 In Malignant Brain Tumor Cell Migration Rasheena Decarroll Edmondson" (2012). Theses. 87.