Preparation and Characterization of Polycaprolactone based Nanofiber Mesh for Biomedical Application

Student Classification


Faculty Mentor

Dr. Narayan Bhattarai


Biomedical Engineering

Document Type


Publication Date

Fall 2019


Nanofiber technology is an increasing interest in the biomedical field of tissue regeneration and drug delivery. Nanofibers have diverse applications due to their high surface area, enabling an increased amount of cells, proteins, and drugs to bind to these structures. Additionally, nanofibrous mesh allows researchers to mimic the physical structure and function of tissue extracellular matrix (ECM), and thus have the potential for tissue engineering applications. Electrospinning process creates the nanofibers in a wide range of lengths and diameters through the application of electrostatic force. Natural or synthetic polymers can be employed in the electrospinning process to make nanofiber mesh. Natural polymers are generally biocompatible, whereas synthetic polymers biocompatibility ranges based on chemical, physical, and structural properties. The polymer of interest for this study is polycaprolactone (PCL), a semi-crystalline polyester that is biocompatible and biodegradable. PCL based nanofiber meshes were fabricated by electrospinning its solutions in trifluoroethanol. To support the potential use of the nanofibrous meshes for biomedical applications their physicochemical properties such as morphology, mechanical strength, and integrity in an aqueous medium, will be studied.

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