Effect of Haemonchus contortus Infection on the Cellular Innate Immune Response of Florida Cracker Sheep During the Peripartum Period
Makenzie Harrison, 3rd-year, Department of Animal Science
Professor Zaira M. Estrada Reyes, Department of Animal Science
Department of Animal Science
Florida cracker sheep are one of the oldest breeds in the United states and are known for their great resistance to parasites. The objective of this research was to evaluate the effects of Haemonchus contortus infection on the cellular innate immune response of pregnant ewes during the peripartum period. A total of eight ewes were used for this study. Experimental sheep were allocated into infected (n = 4) and noninfected (n = 4, control) groups. The infected group was orally administered 10,000 H. contortus larvae. Phenotypic records for the experimental sheep included fecal egg count (FEC), FAMACHA score (FAM), body condition score (BCS), and average daily gain. Hematological parameters were collected at 0 hours, 2 hours, 4 hours, 6 hours, and 3, 7, and 14 days post infection. For the infected group, an increase in white blood cell count was observed at 2 and 6 hpi, and 7 dpi when compared to the control group. Similar results were observed for neutrophil count. The infected ewes showed an increase for neutrophil counts at 2 and 6 hpi, and 3 and 7 dpi.The observed increase in neutrophil levels of infected animals could be one of the first cellular mechanisms associated with the innate immune response.
Harrison, Makenzie, "Effect of Haemonchus contortus Infection on the Cellular Innate Immune Response of Florida Cracker Sheep During the Peripartum Period" (2023). Undergraduate Research and Creative Inquiry Symposia. 304.