Binge alcohol exposure increases depressive-like behavior in adulthood, but not during adolescence, in female C57BL/6J mice

Student Classification


Faculty Mentor

Dr. Antoinette Maldonado-Devincci



Document Type


Publication Date

Fall 2019


Adolescence is a developmental stage in which important maturational changes occur in the brain and in behavior. With adolescent binge drinking still rising, various studies have examined its long-term effects. The present set of experiments aimed to determine the (Exp. 1) intermediate and (Exp. 2) long-term changes in depressive-like behavior following adolescent binge alcohol exposure in male and female mice. Male and female mice were exposed to binge alcohol during adolescence using a vapor inhalation model, in which mice were exposed to four intermittent cycles of alcohol; or air as a control; from postnatal day (PND 28- 42). Mice were given at least one week between ethanol or air exposure and depressive-like behavior was assessed using the tail suspension test on PND 51, 65, and 79 in Exp 1 and on PND 70 in Exp 2. Data were quantified as latency to immobility and total time immobile over six minutes. On PND 51, the ethanolexposed females showed higher latency to immobility compared to air-exposed female mice. In the following trials PND 65 and 79) air-exposed females showed a higher latency to immobility. Males did not show changes in latency to immobility at any test. There were no differences between any groups in total time immobile Exp. 1. In Experiment 2, females exposed to ethanol showed greater total time immobile on PND 70 compared to air-exposed females and ethanol-exposed males. Together, these data show that binge alcohol exposure during adolescence induces a depressive-like phenotype later in adulthood, but not during adolescence.

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