Impact of high fat diet on sensorimotor integration in C57/BL6 mice

Student Classification


Faculty Mentor

Dr. Jessica Han



Document Type


Publication Date

Fall 2019


The exposure to a high fat diet in youth and its impact on brain development and sensorimotor skills are currently unknown. The purpose of this study is to determine the critical stages of when sensorimotor integration begin to decrease. One-month old male and female C57BL/6 J mice were given either a control diet (10% calorie from fat) or a high fat diet (45% calorie from fat). The dietary consumption and body weight were monitored weekly and blood glucose level was measured monthly. After two months, we observed that the high fat male mice had a significant decrease in diet consumption compared to control (p<0.05). Males gained more weight than females when given the high fat diet (p<0.05). We measure the sensorimotor integration with both stride length and adhesive removal behavioral tests. Using a two-ANOVA data analysis, the data shows that there was no significant effect of diet and time on sensorimotor behaviors at the end of two months with dietary treatment. The study is currently ongoing, with the expectation that difference in sensorimotor integration between the control and high fat diet mice will continue to grow.

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