Design and Computational Modeling of a Chemically-Inducible Variant of the Protein Kinase, Akt1
Student Classification
Sophomore
Faculty Mentor
Robert Newman, Ph.D.
Department
Department of Biology
Document Type
Poster
Publication Date
Fall 2019
Disciplines
Biology
Abstract
Protein phosphorylation, mediated by protein kinases, is one of the most widespread regulatory mechanisms in eukaryotes. Inside the cell, protein kinases, phosphatases, and their respective substrates are organized into integrated phosphorylation networks that govern nearly all aspects of cellular physiology. Likewise, dysregulation of these pathways leads to a variety of pervasive diseases, including cancer and diabetes. Unfortunately, due to the complexity of cellular phosphorylation networks, it has been difficult to dissect the functional roles of individual kinases within a given cellular network. Here, we describe the design, computational modeling and initial construction of a chemically-inducible variant of the canonical serine/ threonine protein kinase, AKT1. Successful construction of this new molecular tool will lead to a better understanding of the effect that AKT1 has on the cellular signaling system as a whole.
Recommended Citation
Peagler, Correggio, "Design and Computational Modeling of a Chemically-Inducible Variant of the Protein Kinase, Akt1" (2019). Undergraduate Research and Creative Inquiry Symposia. 92.
https://digital.library.ncat.edu/ugresearchsymposia/92