Date of Award

2013

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Systems Engineering

First Advisor

Li, Zhichao

Abstract

Coronary stents are slotted tubes made of metals, alloys, or polymers. They are deployed in human arteries, which are blocked by calcified plaque, to keep the arteries open and allow the blood to flow with ease. Coronary stents have been proven as an effective treatment device for heart diseases such as acute myocardial infarction. Design plays an important role for coronary stents to perform the clinical functions properly. Various parameters such as materials, structures, dimensions, and deployment methods etc., need to be considered in the design of coronary stents. There are numerous studies on design of coronary stents and many significant manufacturing methods have been reported in the past two decades. However, there is no comprehensive methodology for the product development of coronary stents in terms of design, simulation, and manufacturing. The objective of this research is to develop a methodology for coronary stents product development that focuses on design, simulation, and manufacturing. The methodology brings together insights from numerous engineering design disciplines with the aim of making coronary stent development more flexible and more cost-efficient The product development methodology for coronary stents is executed through modeling and analyzing stent designs with details of design, simulation, and optimization methods. Three innovative stent designs are modeled using engineering design software (SolidWorks) and mechanical performances are simulated, evaluated, and optimized with the help of advanced engineering simulation software (ANSYS). In this study, the performance of stents based on stress, strain, and total deformation during deployment are analyzed and compared with commercially available optimal design i.e., Cypher (J & J Co.) stent, which acts as a benchmark design.

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