Synthetic Tuning of Triangular Silver Nanoplates for Shape-Dependent Antimicrobial Activity

Department

College of Science and Technology, North Carolina Agricultural and Technical State University, 1601 E Market St, Greensboro, NC 27411, USA

Document Type

Poster

Publication Date

4-17-2026

Abstract

Triangular silver nanoplates (AgNPs) are two-dimensional silver nanoparticles with a triangular morphology and typical side lengths from 25-50 nm that show promise as antimicrobial agents. Silver ions, which notably lack biological function, can delay the development of evolutionary antimicrobial resistance by disrupting core bacterial processes. While resistance to silver ions can still develop, preliminary data has shown that continuous exposure of successive generations of bacteria to AgNPs, compared with other nanoparticle geometries, leads to sensitization rather than resistance. However, the mechanism underlying this effect remains unknown. Investigating this requires reliable procedures to control the degree of AgNP corner truncation relative to edge length, which are currently limited. Here we show that concentration of AgNPs synthesized through the chemical reduction method plays an important role in the degree of corner truncation and rounding. Additionally, trisodium citrate can be used as a stabilizing solvent for AgNPs to limit this effect. We anticipate that this work can be used to study the structure–function relationship between AgNP corner truncation and antimicrobial activity.

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