Date of Award

2013

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biological Science

First Advisor

Yun,Yeoheung

Abstract

Magnesium and magnesium alloys are emerging as possible novel biodegradable materials for medical implants such as cardiovascular stents. Understanding the angiogenic properties of magnesium would increase the level of knowledge regarding the healing process once the material is implanted. The chick chorioallantoic membrane assay is an effective, inexpensive method of assessing magnesium's angiogenic properties. The assay is more informative than an in vitro model, in terms of magnesium degradation environment, and provides similar results of an in vivo model. This model can be used as a preliminary method of assessing results before investing labor and finances into larger in vivo models. The corrosion results of magnesium alloys in an in vivo environment and in vitro environment yield insight towards the byproducts of the implant, once degradation has occurred. Immersion test results compared to the in vivo chorioallantoic membrane assay results have shown the behavior of two specific magnesium alloys-AZ31 and Mg-5Zn-0.3Ca. Full comprehension of the angiogenic process stimulated by magnesium will assist in the development of magnesium implants that are more effective treatment methods for many medical applications.

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