Evaluating the Mechanical Properties of 3D Printed Oral Thin Films Using a Texture Analyzer

Student Classification

Asmaa Alawbali, Junior, Chemical Engineering Farzana Rony, PhD Candidate, Applied Chemistry Brian Rogers, MS, Bioengineering

Faculty Mentor

Dr. Mohammad A Azad, Chemical, Biological, and Bioengineering (CBBE)

Document Type

Poster

Publication Date

Spring 2023

Abstract

Research in 3D-printed oral thin films become more prevalent in the pharmaceutical field due to ease of development, personalization, and swallow improvement, especially for geriatric and pediatric patients. The film’s mechanical properties are crucial in assessing the strength and quality of the film. The mechanical properties of a film help ensure that the film is suitable for handling, transportation, storage, and oral delivery. This research aims to evaluate the mechanical properties of 3D-printed thin films using the Texture Analyzer (model TA XT plus C, Stable Microsystems, UK). For thin-film evaluation of mechanical properties testing such as tensile strength (TS), elongation at break (E), and Young’s modulus (YM) are critically important. This testing is an essential quality control parameter for film manufacturing. Sodium alginate-based and Hydroxypropyl methylcellulose (HPMC, K100M)-based 3D printed films were used to conduct the mechanical test using miniature grips. The film dimensions were 15 x10 x 0.35 mm. The test was conducted at a pre-speed of 0.5 mm/s, test speed of 1 mm/s, and post-speed of 10 mm/s. The TS (MPa), E (%), and YM (MPa) were computed, analyzed, and compared with literature studies. The results of the testing exhibited proper mechanical properties and identified the film’s suitability to use.

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