Contributors
Supported by the Genomic Research and Data Science Center for Computation and Cloud-Computing (GRADS-4C) under Grant #U24HG013013
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Description
Poster presented at the National Council of Honors Conference in Kansas City, Missouri
Triple negative breast cancer (TNBC) is comprised of heterogenous tumors that are estrogen receptor, progesterone receptor, and HER2 negative. These tumors are aggressive and present a 40% higher mortality rate amongst African American patients. The causation and pathogenesis of this phenotype and the basis of health disparities are not well understood. MicroRNAs are small, noncoding RNAs that regulate gene expression through the process of mRNA degradation or interference of mRNA translation. The objective of this project was to determine the differential expression of known and novel microRNAs in TNBC in women of European Ancestry (EA) and African Ancestry (AA). We found the differential upregulation and downregulation of in AA and EA. It is possible that the differentially expressed miRNAs found may be involved in regulating TNBC pathogenesis and health disparities. Further studies are in progress address this question.
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PNG
Keywords
triple negative breast cancer, TNBC, heterogenous tumors, estrogen receptor negative, progesterone receptor negative, HER2 negative, health disparities, African American patients, microRNAs, noncoding RNAs, gene expression, mRNA degradation, mRNA translation, differential expression, European Ancestry, African Ancestry, miRNAs, upregulation, downregulation, TNBC pathogenesis, health disparities research