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This study investigates the prevalence and characteristics of ceftriaxone-resistant Enterobacteriaceae (CRO-E) in malnourished children in Malawi, focusing on multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Enterobacter species. CRO-E pose significant health risks, particularly in Sub-Saharan Africa, where limited access to carbapenems results in resistance to the most potent available antibiotics. Given the region's high rates of childhood malnutrition, this research explores the increased risk of CRO-E intestinal colonization in malnourished patients. The study hypothesizes that colonization will be predominantly driven by one morphologically distinct strain of CRO-E within this population, contributing to our understanding of antimicrobial resistance in resource-limited settings.