Development of 3D Printed Thin Film for Oral Delivery of Pharmaceutical Active

Student Classification

Destinee Clay, Senior, Chemical Engineering Farzana Rony, PhD Candidate, Applied Chemistry Brian Rogers, MS, Bioengineering Research

Faculty Mentor

Dr. Mohammad A Azad, Chemical, Biological, and Bioengineering (CBBE)

Document Type


Publication Date

Spring 2023


Polymer-based film as a final dosage form for oral delivery of the pharmaceutical drug or active became popular due to ease of manufacturing and patient compliance, especially for geriatric and pediatric patients' swallow improvement. Merging 3D printing technology with oral thin film development has become attractive due to making the film personalized and tunable. This research aims to develop a 3D-printed thin film to orally deliver pharmaceutical active or drug Fenofibrate (FNB), a cholesterol-reducing drug, with targeted loading of 20% (w/w). Sodium alginate-based ink or paste formulated with cross-linked biopolymer sodium starch glycolate (SSG) was developed using a Thinky mixer (ARE-310) operated at 2000 rpm for 10 minutes. SSG improves ink rheological properties. Rheological properties of the ink were evaluated by flow/viscosity, amplitude sweeps, and thixotropy tests using Anton Paar MCR 302 rheometer. The thin film of dimensions (15 x10 x0.35 mm) was designed, printed using ink, and subsequently dried in an oven at 40°C. The printing parameters were 50% infill density, 60 kPa pressure, and 10 mm/s speed. Overall, a 3D-printed thin film for oral delivery was successfully developed.

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